Saturday, 8 April 2006

Autism and Hormones

Something I'd missed, a Press Release from the University of Wisconsin-Madison, dated August 24 2005. Well, I was kinda distracted then, and it's not exactly daily reading for me at the best of times. :
Gender politics aside, every biologist knows that men and women truly are different.

Social disorders such as autism constitute one area where those differences come to the fore: around 80 percent of all autism cases, for example, occur in men. Social play behaviors also differ greatly between the sexes—just about everyone agrees that young boys play "rougher" than girls.

Early in human development, critical brain proteins known as steroid receptors lay most of the groundwork for ensuing sexual destinies. The receptors bind to hormones such as testosterone and estrogen and set in motion gender blueprints for a lifetime.

To understand why autistic children have trouble engaging in social interactions, researchers have long observed "rough-and-tumble" play—the propensity to bite, wrestle or pounce—in juvenile rats. Scientists were convinced that testosterone solely dictated the onset of such behavior.

But researchers at UW-Madison have now made the surprising finding that estrogen-and even dopamine, a neurotransmitter-also play critical roles. The work, which appeared online Aug. 16 in the journal Endocrinology, may one day help diagnose new autism cases and potentially pave the way for new hormone-based therapeutic approaches that counteract the social difficulties of autism, says senior author Anthony Auger, an assistant professor of psychology.

"Our work points out an overlooked mechanism that controls social play behavior," says Auger. "Now if we work to understand how these biological mechanisms control social behavior, we can discern which points of the various pathways are involved in the disruption of social interactions."

Male rats are likely to engage in rough-and-tumble play almost 13 times as frequently as females, says Auger. But when the UW-Madison team treated newborn females with estrogen, they bit, boxed, pinned and pounced as frequently as the males after reaching juvenile age. The estrogen effectively "masculinized" the females, Auger says.

To the scientists' surprise, a similar result took place when they treated the females with a mimic of the neurotransmitter dopamine, a chemical messenger in the brain that regulates emotions and feelings of pleasure.

The UW-Madison study results imply that many factors, beyond steroid receptors and sex hormones, may be interrupted during the onset of social disorders, Auger says. Consequently, he hopes to focus on the potential role of another group of proteins - known as growth factors - in social play behaviors.

Other scientists who participated in the study include UW-Madison doctoral student and lead author Kristin Olesen, zoologist Catherine Auger and research specialist Heather Jessen.

These are all parts of a puzzle. You see, despite Autism as being seen as a "male disease", it also aflicts a greater than expected number of TS women. That is, people who are genetically and somatically male, but neurally at least partially female. There's even a special Yahoo Support Group because so many people have both Autism or Aspergers, and Transsexuality.
There is known to be a statistically significant correlation between Asperger's Syndrome and Gender Dysphoria but the nature and implications of the link are unknown. Having both of these conditions is quite a plateful and gives us special challenges.

To put it mildly.

Interestingly enough, when my metabolism went hormonally berserk, I lost the minor symptoms I had of a mild case of Asperger's, indicating that the problem may be at least partially hormonal, as well as connected with congenital neuroanatomy. We just don't know, like so much else to do with the brain, gender, and hormonal influences.

1 comment:

Edward said...

Asperger's in males is really the consequence of a female brain in a male body with male hormones, and in females vice versa.

You can fix many of the physical/firmware symptoms by fixing the hormones, but fixing the psychological/software side is rather more complicated at an adult age, as you have to essentially rewrite your own self-schema.

The problem is, for many people, having been told they have an incurable neurological disorder with a presently uncertain etiology, they don't automatically jump to the conclusion that their brain of is the opposite sex, and thus don't seek any treatment at all, believing that none exists.

It's a bit of a screw up in all directions. Just think though, throughout human history all these famous artists, scientists and inventors, have actually been women, who didn't know they were.