A Transgender Therapy Primer - The Body
The basics of Hormone Replacement Therapy. Especially useful is the partial drug interaction chart.
Hormone Replacement Therapy for
This is a Powerpoint Presentation on "what is a hormone?". I disagree in some minor ways with some of the details, but close enough.
There's also a handy list of references for use in educating your GP and Endo. This includes not just articles, but lists of useful websites on the subject. Highly recommended.
The latest version of the (draft) Diagnostics and Statistical Manual from the American Psychiatric Association. Compared to the previous draft, there have been quite a few changes in the area to do with Transsexuality.
Gender Dysphoria, as it is now called, rather than "Gender Identity Disorder", has its own section now. This emphasises its peculiar nature as the mental illness you have when you're not mentally ill.
Please find below a list of disorders that are currently proposed for the diagnostic category, Gender Dysphoria. This category contains diagnoses that were listed in DSM-IV under the chapter of Sexual and Gender Identity Disorders.Unusual? Try "Unique". Try "Sticks out like dog's..." um, you know. Try "obviously doesn't belong but if we don't put it here the consequences would be Bad News(tm) for the patients". Now Intersexed people with the wrong assignment of their sex by others at birth are included as not-mentally-ill-but-in-the-diagnostic-manual anyway too. Well, at least they're consistent...
In response to criticisms that the term was stigmatizing, we originally proposed to replace the term “Gender Identity Disorder” with Gender Incongruence. This was accompanied by a re-definition of the condition, revised criteria, eliminating the previous subtype pertaining to sexual attraction, and introducing a new subtype categorization that does not exclude such individuals with a somatic disorder of sex development (DSD). We chose the new term, Gender Incongruence, as descriptive and to avoid a presupposition of the presence of a clinically significant acute distress in all cases as a requirement for the diagnosis. In part, this was based on more general discussions in the DSM-5 Task Force on separating out the distress/impairment criterion and evaluating these parameters as a separate dimensions.
We also debated and discussed the merit of placing this condition in a special category apart from (formerly Axis-I) psychiatric diagnoses to reflect its unusual status as a mental condition treated with cross-sex hormones, gender reassignment surgery, and social and legal transition to the desired gender (particularly with regard to adolescents and adults). We chose not to make any decision between its categorization as a psychiatric or a medical condition and wished to avoid jeopardizing either insurance coverage or treatment access (Drescher, 2010).
SubtypesMaybe, just Maybe, hypothetically speaking of course, being castrated as a baby might just make one a tadge upset, so yes, there would be issues there. This is in addition to the problems of Gender Dysphoria (not Gender Incongruence now I think). I've seen no real difference in those with diagnosable Intersex conditions who transition, and those without. Often, and I'm starting to think it's the majority, the latter have sub-clinical IS conditions anyway, it's getting beyond a joke the number who do.
With a disorder of sex development 
Without a disorder of sex development
14. There is considerable evidence individuals with a DSD experience GI and may wish to change from their assigned gender; the percentage of such individuals who experience GI is syndrome-dependent (Cohen-Kettenis, 2005; Dessens, Slijper, & Drop, 2005; Mazur, 2005; Meyer-Bahlburg, 1994, 2005, 2009a, 2009b). From a phenomenologic perspective, DSD individuals with GI have both similarities and differences to individuals with GI with no known DSD. Developmental trajectories also have similarities and differences. The presence of a DSD is suggestive of a specific causal mechanism that may not be present in individuals without a diagnosable DSD.
A work in progress. Or perhaps regress in some ways. Whatever, this document will have very real effects on tens of thousands of people's lives. Child custody arrangements for example - for who would place children in the care of a "nutcase"? Human Rights - again, it's easy to say that claims by the insane can be safely ignored. Especially since in the current DSM-IV-TR manual they - we - are classed in the same group as paedophiles, sadists etc.
At least there's an attempt at finding an evidential basis now. I wish they'd get off the fence and accept that the preponderance of evidence for biological causation is now beyond reasonable doubt.