J Clin Endocrinol Metab. 2008 Jan;93(1):182-9
A 46,XY mother who developed as a normal woman underwent spontaneous puberty, reached menarche, menstruated regularly, experienced two unassisted pregnancies, and gave birth to a 46,XY daughter with complete gonadal dysgenesis.
Klinefelter syndrome is a condition related to the X and Y chromosomes (the sex chromosomes). People typically have two sex chromosomes in each cell: females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Most often, Klinefelter syndrome results from the presence of one extra copy of the X chromosome in each cell (47,XXY).
Some people with features of Klinefelter syndrome have more than one extra sex chromosome in each cell (for example, 48,XXXY or 49,XXXXY). These conditions, which are often called variants of Klinefelter syndrome, tend to cause more severe signs and symptoms than classic Klinefelter syndrome
Some people with features of Klinefelter syndrome have the extra X chromosome in only some of their cells; in these individuals, the condition is described as mosaic Klinefelter syndrome (46,XY/47,XXY). Individuals with mosaic Klinefelter syndrome may have milder signs and symptoms, depending on how many cells have an additional X chromosome.
John Calvin, sermon no. 8 on 1st Corinthians, 677, cited in John Calvin: A Sixteenth Century Portrait by William J. Bouwsma (Oxford Univ. Press, 1988), A. 72
Scientific Ignorance and Religion - twas ever thus."Those who assert that 'the earth moves and turns'...[are] motivated by 'a spirit of bitterness, contradiction, and faultfinding;' possessed by the devil, they aimed 'to pervert the order of nature.'"