Monday 24 May 2010

Genes Involved in Male Sexual Development

Gene

Chromosomal Region

Associated syndrome when mutated (m) or duplicated (D)

OMIM Number

SRY

Yp11

46,XY gonadal dysgenesis, Swyer syndrome (M)

480000

SF1

9q33

46,XY gonadal dysgenesis with adrenal failure

184757

DHH

12q12-q13.1

46,XY gonadal dysgenesis (M)

605423


From Genetics of Sex Determination

There's more to it than having a Y chromosome... or even an SrY complex somewhere.

2 comments:

M Italiano said...

HI Zoe, What about the OMIM numbers for SOX9 and DAX1 which also cause XY sex reversal with gonadal dysgenesis?

Zoe Brain said...

Good point. The science here is advancing so quickly though, I can't blame them for the omission. I'm just keeping it as a reference, because although many people know about SrY, few know the others. And I can never remember the names.