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A Very Impressive Naga with a 7-headed Dragon's tongue...
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Guarding the Golden Buddha
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And at another Buddhist shrine entirely, the Boddhisatva Kuanyin
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Intermittent postings from Canberra, Australia on Software Development, Space, Politics, and Interesting URLs.
And of course, Brains...
How alike are you and me? About 99.5%
Nearly six years after the sequence of the human genome was sketched out, one might assume that researchers had worked out what all that DNA means. But a new investigation has left them wondering just how similar one person's genome is to another's.
Geneticists have generally assumed that your string of DNA 'letters' is 99.9% identical to that of your neighbour's, with differences in the odd individual letter. These differences make each person genetically unique — influencing everything from appearance and personality to susceptibility to disease.
But hold on, say the authors of a new study published in Nature1. They have identified surprisingly large chunks of the genome that can differ dramatically from one person to the next. "Everyone has a unique pattern," says one of the lead authors, Matthew Hurles at the Wellcome Trust Sanger Institute in Cambridge, UK.
The differences in question - made up of stretches of DNA that span tens to hundreds of thousands of chemical letters — are called 'copy-number variants', or CNVs. Within a given stretch of DNA, one person may carry one copy of a DNA segment, another may have two, three or more. The region might be completely absent from a third person's genome. And sometimes the segments are shuffled up in different ways.
These variable regions received short shrift for many years. When the human genome sequence was pieced together, they were largely glossed over, because researchers were focused on finding one overarching reference sequence — and because the repetitive nature of the segments makes them hard to sequence. "It was swept under the rug," says Michael Wigler who is also mapping CNVs at Cold Spring Harbor Laboratory, New York.
...
They found nearly 1,500 such regions, taking up some 12% of the human genome. That doesn't mean that your DNA is 12% different from mine (or 88% similar), because any two people's DNA will differ at only a handful of these spots.
According to the team's back-of-the-envelope calculations, one person's DNA is probably 99.5% similar to their neighbour's. Or a bit less. "I've tried to do the calculation and it's very complicated," says Hurles. "It all depends on how you do the accounting."
The answer is also unclear because researchers think that there are many more variable blocks of sequence that are 10,000 or 1,000 letters long and were excluded from the current study. Because of limits with their methods, the new map mainly identified variable chunks larger than 50,000 letters long.
Many of these CNVs are thought to be important in our biology. The team found that 10% of human genes are spanned by these regions, meaning that they might be doubled, deleted or otherwise jumbled in a way that could help to determine whether and when we develop diseases.
It was the late nineties, and Thanksgiving dawned rainy and dismal, the water coming down throughout the day in waves that chilled to the very bone. My "home" was a red 1994 Corvette that I thought I had looked hot in, just six weeks before. I "lived" where it ran out of gas, 2/3 of the way under a freeway overpass in the Los Angeles area. I had no money, no home, no job, no family and no friends. Six weeks earlier I had run out of hormones and couldn't get to the one clinic that would give them to me for free, so I was going through horrendous menopausal symptoms. I hadn't eaten in two days. Everything I owned was wet, and I was chilled to the bone.
In the afternoon, I walked to a pay phone and put in a collect call to my parents, who lived in a house on a golf course that I had bought them. Prior to that, they had lived in a trailer, as did everyone else in my family but me. My mother answered the phone.
"Will you accept a collect call from D____ D_______?"
Silence.
"Ma'am, will you accept a collect call from D____ D_______?"
More silence, though I could hear people in the background. My family members. Music. Clinking of glasses or dishes. Finally, "No," followed by the line going dead.
I am feeling really sad today. I am missing out on my girls lives because of me being me. I can't stop loving my ex, and I feel like a horriable person because my eldest os miserable without us all being together.She's still forbidden to have contact with her family.
I feel at lost because my youngest is walking now and i did not get to see her walk. I am missimg so much. Next will be her first word.
A Man stabbed a transsexual with shards from a broken vase after discovering her true gender during an intimate encounter, a Melbourne court heard today.Always tell before things get out of hand - so to speak. Deciding on when and if to tell is a fraught question, get it wrong and...well, if you're lucky you survive. But ethically you have to, before things go too far.
Clinton Dwayne McRae, 28, of Pakenham, today pleaded guilty in the Victorian County Court to intentionally seriously injuring the woman after going to bed with her last January.
McRae met a person he believed to be a woman at a Southbank club. They returned to the 41-year-old woman's city apartment where she stripped to her underwear and they got into bed together, the court heard.
As they started to become intimate she jumped out of the bed and told him she was transsexual, she told the court.
McRae then punched her several times, grabbed her hair and yelled: “You're a f---ing freak ... I'm going to kill you,” she told the court.So let's see, he causes her to beg for her life, causes her to flee in terror from her home, stabbed, bashed, and bleeding, puts her in hospital for four days and he's the victim, who will need trauma councelling?
“I begged for my life. I got down on my knees and asked for forgiveness,” she said.
She said she grabbed a ceramic vase which McRae took from her. He hit her on the head with it and stabbed her with a broken portion of the vase.
She said she escaped and hid outside her apartment and McRae then left.
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In an interview with police, McRae said any “red-blooded male” would have been angry if faced with his situation.
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“I am going to need mental counselling after what's happened.”
The woman spent four days in hospital and suffered lacerations to the chest, shoulder and torso, Crown prosecutor Gabriele Cannon told the court.
"This is not the End. This is not even the Beginning of the End. But it is, perhaps, the End of the Beginning."Exactly so.
UFO sightings and alien visitors tend to be solely the reserve of sci-fi movies.
So when a former MoD chief warns that the country could be attacked by extraterrestrials at any time, you may be forgiven for feeling a little alarmed.
During his time as head of the Ministry of Defence UFO project, Nick Pope was persuaded into believing that other lifeforms may visit Earth and, more specifically, Britain.
His concern is that "highly credible" sightings are simply dismissed.
And he complains that the project he once ran is now "virtually closed" down, leaving the country "wide open" to aliens.
Mr Pope decided to speak out about his worries after resigning from his post at the Directorate of Defence Security at the MoD this week.
"The consequences of getting this one wrong could be huge," he said.
>>Peers in the House of Lords last week debated the changes, which allow homoeopathic medicines to make medicinal claims. In September, the Medicines and Healthcare Products Regulatory Agency (MHRA) introduced a scheme to regulate homoeopathic products in the United Kingdom,The Labour Minister of Health, Lord Warner disagreed using the following justification:
which allows manufacturers to specify the ailments that preparations can be used for.
These changes have led to an outcry from much of the scientific and medical world, says the Liberal Democrat Lord Taverne, who led the debate and called for the regulations to be annulled.
"This regulation was made explicitly for the benefit of the manufacturers of homoeopathic products," he said. "For the first time in the history of the regulation of medical products, it allows claim of efficacy to be made without scientific evidence. It is an abandonment of science and the evidence based approach.
"When homoeopathic substances have been tested scientifically, no evidence has been found that they work any more than as a placebo. It is the equivalent of witchcraft."
"Because homoeopathic products are different from conventional medicines, it is right, in our view, that they are regulated in a different way. They cannot demonstrate efficacy in the same way that conventional medicinal products are required to do to obtain a licence."In other words, they don't work, so no point trying to prove they do. All the regulations do is to require distilled water of the right kind to be used, rather than plain old ordinary distilled water, tap water, or something actually poisonous.
Neanderthals may have given the modern humans who replaced them a priceless gift -- a gene that helped them develop superior brains, U.S. researchers reported Tuesday.
And the only way they could have provided that gift would have been by interbreeding, the team at the Howard Hughes Medical Institute and the University of Chicago said.
Their study, published in the Proceedings of the National Academy of Sciences, provides indirect evidence that modern Homo sapiens and so-called Neanderthals interbred at some point when they lived side by side in Europe.
"Finding evidence of mixing is not all that surprising. But our study demonstrates the possibility that interbreeding contributed advantageous variants into the human gene pool that subsequently spread," said Bruce Lahn, a Howard Hughes Medical Institute researcher at the University of Chicago who led the study.
...
Lahn's team found a brain gene that appears to have entered the human lineage about 1.1 million years ago, and that has a modern form, or allele, that appeared about 37,000 years ago -- right before Neanderthals became extinct.
...
They noted that this D allele is very common in Europe, where Neanderthals lived, and more rare in Africa, where they did not. Lahn said it is not yet clear what advantage the D allele gives the human brain.
"The D alleles may not even change brain size; they may only make the brain a bit more efficient if it indeed affects brain function," Lahn said.
2.1 Definitions
The experience of this dissonance between the sex appearance and the sense of being male or female is termed gender dysphoria. The diagnosis should not be taken as an indication of mental illness.
Appendix A Legal Rights of Transgendered People Section A.1
It should be noted that a Court of Appeal in Madrid ( Katia vs IMSALUD 2003) found that, as an Intersex condition, transsexualism should be treated on an equal basis as other "corrective" intersex surgery.
Fully featured high end MP3
plays MP3, WMA, WAV and OGG Vorbis sound files
Use as a storage device for digital pictures, presentations and more
Voice recorder
FM radio with a record function
Swiss Army knife incorporated in a metal body
Remote control with two earphone connections for parallel listening
Drag and Drop Multimedia Device means no special software just use Windows Explorer to drag and drop
The SWISSMEMORY TM USB Victorinox is a unique accessory, perfect gift or a business tool. The small all-rounder integrates numerous useful tools and is available in two versions: one with a stainless steel knife, scissors, a file and a screw driver and the other without these tools, to carry when travelling on planes (not a stock item). Both versions include a pressurized pen and a light function. 128mb, 256mb and 512mb have a red light. The 1GB and the new 2GB have white light function.
2.5" 60% Serrated locking blade
Nail file, nail cleaner
Corkscrew
Adjustable pliers with wire crimper and cutter
Removable screwdriver bit adapter
2.5" Blade for Official World Scout Knife
Spring-loaded, locking needle-nose pliers with wire cutter
Removable screwdriver bit holder
Phillips head screwdriver bit 0
Phillips head screwdriver bit 1
Phillips head screwdriver bit 2
Flat head screwdriver bit 0.5mm x 3.5mm
Flat head screwdriver bit 0.6mm x 4.0mm
Flat head screwdriver bit 1.0mm x 6.5mm
Magnetized recessed bit holder
Double-cut wood saw with ruler (inch & cm)
Bike chain rivet setter, removable 5mm allen wrench, screwdriver for slotted and philips head screws
Removable tool for adjusting bike spokes, 10mm hexagonal key for nuts
Removable 4mm curved allen wrench with philips head screwdriver
Removable 10mm hexagonal key
Patented locking philips head screwdriver
Universal wrench
2.4" Springless scissors with serrated, self-sharpening design
1.65" Clip point utility blade
Philips head screwdriver
2.5" Clip point blade
Golf club face cleaner
2.4" Round tip blade
Patented locking screwdriver, cap lifter, can opener
Golf shoe spike wrench
Golf divot repair tool
4mm allen wrench
2.5" blade
Fine metal file with precision screwdriver
Double-cut wood saw
Cupped cigar cutter with double-honed edges
12/20-Guage choke tube tool
Watch caseback opening tool
Snap shackle
Mineral crystal magnifier with precision screwdriver
Compass, straight edge, ruler (in./cm)
Telescopic pointer
Fish scaler, hook disgorger, line guide
Shortix laboratory key
Micro tool holder
Micro tool adapter
Micro scraper - straight
Micro scraper - curved
Laser pointer with 300 ft. range
Metal saw, metal file
Flashlight
Micro tool holder
Philips head screwdriver 1.5mm
Screwdriver 1.2mm
Screwdriver .8mm
Fine fork for watch spring bars
Reamer
Pin punch 1.2mm
Pin punch .8mm
Round needle file
Removable tool holder with expandable receptacle
Removable tool holder
Special self-centering screwdriver for gunsights
Flat philips head screwdriver
Chisel-point reamer
Mineral crystal magnifier, fork for watch spring bars, small ruler
Extension tool
Spring-loaded, locking flat nose-nose pliers with wire cutter
Removable screwdriver bit holder
Phillips head screwdriver bit 0
Phillips head screwdriver bit 1
Phillips head screwdriver bit 2
Flat head screwdriver bit 0.5mm x 3.5mm
Flat head screwdriver bit 0.6mm x 4.0mm
Flat head screwdriver bit 1.0mm x 6.5mm
Magnetized recessed bit holder
Tire tread gauge
Fiber optic tool holder
Can opener
Patented locking screwdriver, cap lifter, wire stripper
Reamer/awl
Toothpick
Tweezers
Key ring
Actual Size: 8.75. W x 3.25. L
Weight: 2lbs 11oz
Though the laser pointer's kinda cool.